Effects of Acetaminophen-induced Acute Liver Injury on Endogenous Sub-stances in Rat Brain
Objective To explore the effects of acetaminophen-induced acute liver injury on endogenous substances in rat brain.Methods Twelve male Sprague-Dawley rats were selected from April to June 2023 at Bengbu Medical University and divided into six each of control group(physiological saline gavage)and acetaminophen group(to estab-lish an acute liver injury model by gavage administration)by random number table method.The liver alanine amino-transferase and aspartate aminotransferase activities,brain dopamine and 5-hydroxytryptamine levels and plasma 5-hydroxytryptamine levels were measured in rats.Results The liver alanine aminotransferase and aspartate aminotrans-ferase activities of rats in the acetaminophen group were significantly higher than those of the control group[(30.31±18.02)U/L vs(7.58±1.65)U/L],[(53.53±26.54)U/L vs(16.99±1.35)U/L],and the differences were statisti-cally significant(t=-2.887,-2.882,both P<0.01).Compared with the control group,rats in the acetaminophen group showed an increase of 9.9%and 8.6%within the cortical and hippocampal tissue dopamine content,respectively,and 14.8%,3.1%,and 9.5%within the cortical,hippocampal tissue,and plasma 5-hydroxytryptophan content,respec-tively,but the difference was not statistically significant(all P>0.05).Conclusion Acute liver injury induced by acet-aminophen resulted in a trend toward increased levels of endogenous substances in the rat brain compared with the control group,but there was no statistically significant difference.It is hypothesized that the reason for this result may be the insufficient level of liver injury due to the insufficient dose or frequency of acetaminophen administration.
万方数据
维普
