摘要
目的 探究分析微量泵泵入奥曲肽治疗急性胰腺炎的疗效.方法 选取2020年5月—2023年5月句容市人民医院接受奥曲肽治疗的76例急性胰腺炎患者为研究对象,采用随机数表法分组,每组38例.对照组给予静脉滴注奥曲肽治疗,研究组给予微量泵泵入奥曲肽治疗,分析两组疗效、临床指标(腹痛缓解、恶心呕吐缓解、血淀粉酶恢复、住院时间)、炎症因子(白细胞介素-2、C反应蛋白、肿瘤坏死因子-α)、不良反应等.结果 研究组治疗总有效率(97.37%)高于对照组(84.21%),差异有统计学意义(χ2=4.434,P=0.047).研究组腹痛缓解、恶心呕吐缓解、血淀粉酶恢复、住院时间均优于对照组,差异有统计学意义(P均<0.05).研究组治疗后白细胞介素-2、C反应蛋白、肿瘤坏死因子-α均低于对照组,差异有统计学意义(P均<0.05).研究组不良反应发生率低于对照组,差异有统计学意义(χ2=5.029,P=0.025).结论 急性胰腺炎实施微量泵泵入治疗疗效显著,安全性高,降低炎症情况.
Abstract
Objective To explore the therapeutic effect of octreotide injected by micropump in the treatment of acute pancreatitis.Methods A total of 76 patients with acute pancreatitis treated with octreotide in Jurong People's Hospi-tal from May 2020 to May 2023 were selected as the research objects,and they were divided into two groups by ran-dom number table method,with 38 cases in each group.The control group was treated with intravenous infusion of oc-treotide,and the study group was treated with micro-pump infusion of octreotide.The efficacy,clinical indicators(ab-dominal pain relief,nausea and vomiting relief,blood amylase recovery,hospitalization time),inflammatory factors(in-terleukin-2,C-reactive protein,tumor necrosis factor α)and adverse reactions of the two groups were analyzed.Re-sults The total effective rate of treatment in the study group(97.37%)was higher than that in the control group(84.21%),and the difference was statistically significant(χ2=4.434,P=0.047).The abdominal pain relief,nausea and vomiting relief,blood amylase recovery and hospitalization time in the study group were better than those in the con-trol group,and the differences were statistically significant(all P<0.05).After treatment,the levels of interleukin-2,C-reactive protein and tumor necrosis factor-α in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(χ2=5.029,P=0.025).Conclusion The treatment of acute pancreatitis with micropump is effective,safe and can reduce inflammation.
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