Effect of Low Molecular Weight Heparin and Rivaroxaban on the Forma-tion of Deep Vein Thrombosis of Lower Extremity and the Level of Inflam-matory Factors in Patients with Great Saphenous Varicose Vein after Sur-gery
Objective To explore the effects of rivaroxaban and low molecular weight heparin on postoperative deep vein thrombosis and inflammatory factors in patients with saphenous varicose vein.Methods A total of 62 patients with varicose veins of great saphenous vein admitted to the surgery department of the second Central Health Center of Tongzhou District from January 2020 to June 2023 were selected as the study objects.According to random number table method,the patients were divided into two groups,31 cases in each group,both groups were treated with conven-tional treatment,the reference group was treated with low molecular weight heparin after surgery,and the study group was treated with rivaroxaban.Comparison of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),D-dimer(D-D)in the two groups before and after treatment,thrombin time(TT),fibrinogen(FIB)and other indicators,the inci-dence of deep vein thrombosis,recurrence rate of varicose veins,and the incidence of complications.Results After treatment,CRP,TNF-α,D-D,TT,ESR,index values of low and high cut blood viscosity and incidence of complica-tions in the study group were lower than those in the reference group,and plasma viscosity and FIB levels were higher than those in the reference group,and the differences were statistically significant(all P<0.05).Conclusion The treat-ment of low molecular weight heparin and rivaroxaban for varicose veins of the great saphenous vein after surgery has a preventive effect on the formation of deep vein thrombosis of the lower extremities after surgery.However,rivaroxa-ban for varicose veins of the great saphenous vein can reduce the level of inflammatory factors of the patients,improve the coagulation function and hemorheology indexes of the patients,and can prevent various postoperative complica-tions of the patients to a certain extent,and it has high therapeutic effect.
Low molecular weight heparinRivaroxabanVaricose great saphenous vein
万方数据
维普
