目的 分析早期连续性肾脏替代疗法(Continuous Renal Replacement Therapy,CRRT)+乌司他丁(Ulina-statin,UTI)应用在重症急性胰腺炎(Severe Acute Pancreatitis,SAP)患者中的临床效果.方法 选取公安县人民医院于2023年1-12月收治的80例SAP患者为研究对象,以随机数表法分为两组,各40例.对照组实施早期CRRT治疗、观察组实施CRRT+UTI治疗,比较两组血管内皮功能、炎症因子、急性生理与慢性健康评分(Acute Physiological And Chronic Health Scores,APACHEⅡ)、症状改善时间.结果 治疗后,观察组血管内皮功能、炎症因子水平、APACHEⅡ评分均优于对照组,差异有统计学意义(P均<0.05);观察组肛门排便恢复时间(5.82±1.03)d、发热消失时间(2.89±0.34)d、肠鸣音恢复时间(3.64±0.52)d、腹痛腹胀消失时间(3.68±0.54)d均短于对照组的(9.22±1.52)、(5.10±0.42)、(5.23±0.66)、(6.27±0.89)d,差异有统计学意义(t=11.711、25.866、11.968、15.735,P均<0.05).结论 对SAP患者实施早期CRRT+UTI,可以改善血管内皮功能、炎症状态、临床症状,促进病情转归.
Clinical Effect of Early Continuous Renal Replacement Therapy Com-bined with Ulinastatin in the Treatment of Severe Acute Pancreatitis
Objective To analyze the clinical efficacy of early continuous renal replacement therapy(CRRT)plus ulinastatin(UTI)in patients with severe acute pancreatitis(SAP).Methods A total of 80 SAP patients admitted to Gongan County People's Hospital from January to December 2023 were selected as the study objects and divided into two groups with 40 cases each by random number table method.Control group received early CRRT treatment,obser-vation group received CRRT+UTI treatment.Vascular endothelial function,inflammatory factors,Acute Physiological And Chronic Health Scores(APACHEⅡ)and symptom improvement time were compared between the two groups.Re-sults After treatment,vascular endothelial function,inflammatory factor level and APACHEⅡ score in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The re-covery time of anal defecation(5.82±1.03)d,the disappearance time of fever(2.89±0.34)d,the recovery time of intes-tinal sound(3.64±0.52)d,and the disappearance time of abdominal pain and distension(3.68±0.54)d in the observa-tion group were shorter than those in the control group(9.22±1.52),(5.10±0.42),(5.23±0.66),(6.27±0.89)d,and the differences were statistically significant(t=11.711,25.866,11.968,15.735,all P<0.05).Conclusion Early implemen-tation of CRRT+UTI in SAP patients can improve vascular endothelial function,inflammatory status,clinical symp-toms,and promote the outcome of the disease.
Early continuous renal replacement therapyUlinastatinSevere acute pancreatitis
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