Objective To explore and analyze the relationship between anticardiolipin antibody(ACA)levels and the severity of chronic obstructive pulmonary disease(COPD)combined with pneumonia.Methods A total of 80 COPD pa-tients admitted to Beijing Daxing District People's Hospital from May 2022 to May 2023 were selected as study ob-jects,and the patients were categorized into 61 cases in the COPD group and 27 cases in the COPD-combined pneu-monia group according to whether they were combined with pneumonia or not.Their serum samples were taken at the time of admission,and the serum ACA level was detected by enzyme-linked immunosorbent assay,and the relation-ship between serum ACA and the severity of COPD-combined pneumonia was analyzed by Spearman's correlation analysis.Results Patients in the COPD-combined pneumonia group had higher smoking history,mechanical ventila-tion,C-reactive protein,procalcitonin,and COPD stage than patients in the COPD group,the differences were statisti-cally significant(all P<0.05),while forced vital capacity(FVC)and force expiratory volume in the first second/forced vital capacity(FEV1/FVC)were lower than patients in the COPD group,the differences were statistically significant(both P<0.05).The serum ACA level of patients with COPD-combined pneumonia group(5.27±1.22)RU/mL was higher than that of(2.43±0.56)RU/mL in the COPD group,the difference was statistically significant(P<0.05),and the serum ACA level gradually increased with the increase of COPD stage,and the differences between two compari-sons of the groups were statistically significant(all P<0.05).Spearman analysis showed that serum ACA was positively correlated with C-reactive protein,procalcitonin,and COPD stage(all P<0.01),and serum ACA was negatively corre-lated with FVC and FEV1/FVC(both P<0.01).Conclusion Serum ACA level was decreased in patients with COPD and anticardiolipin antibody was positively correlated with the severity of COPD and pneumonia,which is an impor-tant reference value for the assessment of the severity of the patient's condition.
关键词
慢性阻塞性肺疾病合并肺炎/抗心磷脂抗体/病情严重程度
Key words
COPD combined with pneumonia/Anticardiolipin antibody/Severity of disease
维普
万方数据