Clinical Effect of Different Doses of Octreotide Combined with Endoscopic Ligation in Treating Upper Gastrointestinal Bleeding Complicated by Liver Cirrhosis and Its Effect on Serological Indicators
Objective To explore the effect of different doses of octreotide combined with endoscopic ligation in the treatment of upper gastrointestinal bleeding complicated by liver cirrhosis.Methods A total of 110 patients with liver cirrhosis complicated with upper gastrointestinal bleeding admitted to Guangxi Zhuang Autonomous Region Jiangbin Hospital from January to December 2023 were selected as study objects.They were divided into study group(n=55)and control group(n=55)by random number table method.All patients were treated with endoscopic ligation.The con-trol group was treated with conventional dose of octreotide,and the study group was treated with high dose of octreo-tide.The perioperative related indexes,serological indexes before and after treatment and the incidence of adverse re-actions were compared between the two groups.Results The incidence of 72 h rebleeding in the study group(5.45%)was lower than that in the control group(18.18%),the difference was statistically significant(χ2=4.274,P<0.05).The time of hospital stay and hemostatic,and blood transfusion in the study group were better than those of control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of lipid hydroperoxide(LHP),malondialdehyde(MAD)and advanced oxidation protein products(AOPP)in the two groups decreased,and the level of glutathione peroxidase(GSH-Px)increased,the levels of LHP,MAD and AOPPs in the study group were lower than those in the control group,and the level of GSH-Px was higher than that in the control group,the differences were sta-tistically significant(all P<0.05).Conclusion High-dose octreotide combined with endoscopic ligature treatment for upper gastrointestinal bleeding complicated by liver cirrhosis has a better hemostatic effect,accelerates postoperative recovery,and reduces oxidative stress without significantly increasing adverse reactions.
OctreotideEndoscopic ligationUpper gastrointestinal bleeding complicated by liver cirrhosisClinical effect
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维普
