Clinical Effect of Mifepristone and Progesterone in the Treatment of Peri-menopause Functional Uterine Bleeding
Objective To explore the difference effect between mifepristone and progesterone in the treatment of peri-menopause functional uterine bleeding.Methods A total of 67 patients with peri-menopause functional uterine bleed-ing in Linyi Hospital of Traditional Chinese Medicine from July 2020 to July 2022 were randomly selected as the study object and divided into control group(33 cases)and observation group(34 cases)by random number table method.The control group was treated with progesterone and the observation group was treated with mifepristone.The therapeutic effect,hemostatic time,related clinical indexes,sex hormone levels and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.06%,which was higher than 75.76%of the control group,and the difference was statistically significant(χ2=4.831,P<0.05).The time of controlled hemostasis and complete hemostasis in the observation group were shorter than those in the control group,and the dif-ferences were statistically significant(both P<0.05).After treatment,the menstrual volume and endometrial thickness in the observation group were lower than those in the control group,and the hemoglobin concentration was higher than that in the control group,and the differences were statistically significant(all P<0.05).After treatment,progesterone,estradiol,luteinizing hormone and follicle-stimulating hormone in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the ob-servation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclu-sion In the treatment of peri-menopause functional uterine bleeding,the use of mifepristone treatment program can ef-fectively improve the total effective rate of treatment,shorten the hemostatic time,improve the relevant clinical indica-tors and sex hormone levels,while the adverse reactions are less,the clinical effect and safety are relatively ideal.
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