Effect of Inhibiting Inflammasome Activation on Myocardial Ischemia in Rats
The incidence of coronary atherosclerotic heart disease(CHD)continues to rise,seriously endangering the physical and mental health of residents.Coronary artery stenosis or occlusion caused by coronary atherosclerosis is the most common and critical cause of myocardial ischemia.The main mechanism of cardiac injury and healing is inflam-mation.Excessive inflammation leads to poor ventricular remodeling.Studies have confirmed that Nod-like receptor protein 3(NLRP)inflammasome mediated inflammation can participate in the process of coronary arteriosclerosis,acute myocardial infarction,ischemia/reperfusion injury and cardiac remodeling after atrial fibrillation.Correctly in-hibiting the activation mechanism of NLRP3 inflammasome can slow down the occurrence and development of inflam-matory response,inhibit apoptosis,and effectively prevent and treat cardiovascular diseases.Inhibition of inflamma-some activation can alleviate myocardial ischemic necrosis to a certain extent.
万方数据
维普
