Analysis of the Correlation between Intestinal Flora Dysbiosis and Expres-sion Levels of Immunoglobulins and Inflammatory Factors in Patients with Colorectal Cancer
Objective To explore the correlation between intestinal flora imbalance and the expression levels of immu-noglobulins and inflammatory factors in patients with colorectal cancer(CRC).Methods The clinical data of 74 CRC patients admitted to the Affiliated Hospital of Inner Mongolia University for Nationalities from October 2019 to Novem-ber 2022 were retrospectively analyzed.According to the intestinal flora test results,they were divided into normal flora group(n=32),degree I group(n=22),and degree Ⅱ group(n=20).The intestinal flora,serum inflammatory fac-tors,and immunoglobulin levels of the three groups were detected and compared,and correlation analysis was per-formed.Results Compared with the normal group,the number of colonies of lactobacillus and bifidobacterium in de-gree Ⅰ and group Ⅱ was lower,while the number of colonies of escherichia coli and enterococcus faecalis was higher,the differences were statistically significant(all P<0.05).At the same time,the colony numbers of lactobacillus and bifidobacterium in group Ⅱ[(6.57±0.98),(6.51±0.97)logN/g]were lower than those in group I[(7.53±1.12),(7.74±1.16)logN/g],the differences were statistically significant(both P<0.05).The colony numbers of escherichia coli and enterococcus faecalis[(10.38±1.55),(9.57±1.43)logN/g]were higher than those of the group I[(8.03±1.20),(8.48±1.27)logN/g],the differences were statistically significant(both P<0.05).Compared with the normal group,inter-leukin-6(IL-6),interleukin-22(IL-22),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),immunoglobulin A(IgA),immunoglobulin M(IgM)immunoglobulin G(IgG)levels were all higher in the group I and group Ⅱ,and as the intestinal flora imbalance became more serious,the levels of the above serum inflammatory factors and immuno-globulins were higher,and the differences were statistically significant(all P<0.05).Spearman correlation analysis re-sults showed that intestinal flora imbalance was positively correlated with IL-6,IL-22,IL-17,TNF-α,IgA,IgM,and IgG levels,and the differences were statistically significant(all P<0.05).Conclusion There is a significant correlation between intestinal flora imbalance and the expression levels of immunoglobulins and inflammatory factors in CRC pa-tients.
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