Analysis of Differential Expression of Coagulation and Fibrinolysis Indica-tors in Patients with Lung Cancer at Different Clinical Stages
Objective To explore and analyze the expression differences of coagulation and fibrinolysis indicators in patients with lung cancer at different clinical stages and their correlation with the disease.Methods The clinical data of 156 patients with lung cancer diagnosed and treated in Nantong Ruici Hospital from August 2019 to December 2022 were retrospectively selected as the observation group(100 cases of stage Ⅰ,30 cases of stage Ⅱ and 26 cases of stage Ⅲ),and 100 healthy people who underwent physical examination in the physical examination center of the hospital during the same period were selected as the healthy group.The coagulation and fibrinolysis indexes of all groups were detected and the correlation analysis was carried out.Results The plasma fibrinogen(5.78±0.31)g/L in the observation group was higher than that in the healthy group(2.57±0.21)g/L,the platelet count(234.40±11.58)×109/L in the observation group was higher than that in the healthy group(156.89±12.68)×109/L,and the differences were statistically significant(t=90.996,50.335,both P<0.05).With the increase of clinical stage,the plasma prothrom-bin time,D-dimer and activated partial thromboplastin time of lung cancer patients increased significantly,and the thrombin time time decreased significantly,the differences were statistically significant(all P<0.05).The platelet count and plasma fibrinogen content of patients with stage Ⅲ lung cancer were higher than those of patients with stage Ⅱ and stage Ⅰ,and the differences were statistically significant(all P<0.05).Among 156 patients,Spearsman rank correlation analysis showed a positive correlation between clinical stage and plasma prothrombin time,D-dimer,acti-vated partial thromboplastin time,fibrinogen,and platelets(all P<0.05).Conclusion Lung cancer patients are often accompanied by abnormal expression of coagulation and fibrinolysis indicators,and there is a correlation between the expression of coagulation and fibrinolysis indicators and the clinical staging of lung cancer patients.
万方数据
维普
