Objective To investigate the effect of doxycycline in the treatment of macrolide resistant mycoplasma pneumoniae pneumonia(MPP)in children.Methods A total of 80 children with macrolide resistant MPP treated in the First Affiliated Hospital of Ningbo University from October 2022 to October 2023 were selected as the study ob-jects,and were divided into observation group(n=40)and control group(n=40)according to random number table method two groups.Both groups were given basic intervention such as relieving cough and resolving phlegm,replenish-ing water and liquid.On this basis,the control group was treated with azithromycin for 7 days,and the observation group was treated with doxycycline for 7 days.The clinical therapeutic effect was observed and analyzed between the two groups.Results The clinical total effectiveness rate of the observation group was 95.00%higher than that of the control group(77.50%),and the difference was statistically significant(χ2=5.164,P<0.05).The time for symptomatic relief of the observation group was significantly shorter than that of the control group,and the difference was statisti-cally significant(P<0.05).The levels of serum inflammatory factor indexes,such as serum C-reactive protein,interleu-kin-6,interleukin-17,were lower than those before the treatment,and the observation group was lower than the con-trol group,and the differences were statistically significant(all P<0.05).The level of interleukin-10 was higher than that before treatment,and the observation group was higher than the control group,and the differences were statisti-cally significant(both P<0.05).There was no statistically significant difference in the total incidence of adverse reac-tions between the two groups(P>0.05).Conclusion For children with macrolide resistant MPP,doxycycline treatment has obvious effect,can promote the relief of symptoms in children,reduce the level of inflammatory factors,and has good safety.
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