Application of High-flow Nasal Cannula Oxygen Therapy in the Treat-ment of COPD with Respiratory Failure During Acute Exacerbation
Objective To investigate the effects of high-flow nasal cannula oxygen therapy(HFNC)in patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD)with respiratory failure(RF).Methods A total of 98 patients with AECOPD and RF admitted to Bijie Hospital of Traditional Chinese Medicine from May 2021 to May 2023 were selected and divided into two groups according to random number table method,with forty-nine in cases each group.The control group was treated with noninvasive positive pressureventilation(NPPV),and the observation group was treated with nasal high-flow nasal cannula oxygen therapy.The therapeutic effect of the two groups was compared.Results The total effective rate of the observation group was 93.88%,higher than that of the control group 79.59%,and the incidence of adverse reactions was 4.08%,lower than that of the control group 16.33%,and the dif-ferences were statistically significant(χ2=4.346,4.009,both P<0.05).Before treatment,the peaks of carbon dioxide partial pressure,blood oxygen partial pressure,C-reactive protein,interleukin-6,forced vital capacity and expiratory flow in the two group were compared,and the differences were not statistically significant(all P>0.05).After treat-ment,the partial pressure of carbon dioxide,C-reactive protein and interleukin-6 in observation group were lower than those in control group,while the peak value of blood oxygen partial pressure,forced vital capacity and expiratory flow in observation group were higher than those in control group,and the differences were statistically significant(all P<0.05).Conclusion HFNC can improve arterial blood gas level in patients with AECOPD and RF,control the inflam-matory response of the body,and promote the recovery of lung function with less adverse reactions.
COPD in acute exacerbationRespiratory failureNasal high-flow cannula oxygen therapyAdverse reaction
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