Occurrence of Adverse Reactions and Clinical Evaluation of Sequential Treatment of Symptomatic Intracranial Artery Stenosis with Severe Cere-bral Infarction with Butylphthalein
Objective To analyze the therapeutic effect of sequential application of butylphthalein in patients with symptomatic severe intracranial artery stenosis and cerebral infarction.Methods A total of 116 patients with symptom-atic intracranial artery severe stenosis cerebral infarction admitted to Shouguang People's Hospital of Shandong Prov-ince from January 2020 to October 2023 were selected as the research objects.They were randomly divided into refer-ence group and observation group by double-blind method,with 58 cases in each group.The reference group was treated with routine treatment,and the observation group was treated with butylphthalide sequential therapy.The reha-bilitation efficiency,vascular endothelial function,neurological function index,neurological deficit score and inci-dence of adverse reactions were compared between the two groups.Results The effective rate of rehabilitation in the observation group was 94.83%,which was significantly higher than 82.76%in the reference group,and the difference was statistically significant(χ2=4.245,P=0.039).After treatment,the vascular endothelial function,neurological func-tion index and neurological deficit score of the observation group were better than those of the reference group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The sequential treatment of butylphthalein com-bined with conventional treatment in patients with symptomatic severe intracranial artery stenosis and cerebral infarc-tion has a definite effect,the safety is high.
Symptomatic intracranial artery severe stenosis cerebral infarctionButylphthaleinSequential treatmentCurative effectAdverse reaction
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