Effect of Montelukast Sodium and Ketotifen in the Treatment of Pediatric Cough Variability Asthma on the Time of Cough Symptom Disappearance and the Time of Recovery of Respiratory Function Indicators
Objective To investigate the clinical effect of the application of montelukast sodium and ketotifen in the treatment of pediatric cough variant asthma(CVA)and its impact on prognosis.Methods The clinical data of 98 chil-dren with CVA admitted to the Fourth People's Hospital of Zigong City from January 2022 to September 2023 were retrospectively selected and divided into a control group and an observation group of 49 cases each with different treat-ment methods.The control group was treated with montelukast sodium alone,and the observation group was treated with montelukast sodium and ketotifen.The two groups were compared in terms of clinical efficacy,disappearance time of cough symptoms,recovery time of respiratory function indexes,lung function,inflammation level,and immune function indexes.Results The clinical efficacy rate in the observation group was 93.88%,which was higher than that of 79.59%in the control group,the difference was statistically significant(χ2=4.346,P<0.05).Comparing with the con-trol group,the observation group's cough symptoms disappeared and the recovery time of respiratory function indexes were shorter,the differences were statistically significant(both P<0.05).The forced expiratory volume in one second,forced expiratory volume in one second/forced vital capacity,and peak expiratory flow of the two groups showed a ten-dency to increase after the treatment,and the observation group was better than the control group,the differences were statistically significant(all P<0.05).Tumor necrosis factor-α,immunoglobulin E,and helper Tcell 1 assay values showed a decreasing trend,and interleukin-4 and regulatory Tcell assay values showed an increasing trend after treat-ment in both groups,and the observation group was better than the control group,the differences were statistically sig-nificant(all P<0.05).Conclusion In the treatment of pediatric CVA,the combination of montelukast sodium and keto-tifen can achieve precise efficacy,which can improve cough symptoms and respiratory function,improve lung function,and alleviate the level of inflammation.
Montelukast sodiumKetotifenCough variant asthmaTime to disappearance of cough symptomsRespiratory function
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