Stress Response Analysis of Brachial Plexus Block Combined with General Anesthesia in Operation of Upper Limb Fracture in Children
Objective To investigate the stress response of brachial plexus block combined with general anesthesia in children with upper limb fracture surgery.Methods Clinical data of 120 children with upper limb fractures diagnosed and treated in Tengzhou Central People's Hospital from March 2020 to March 2023 were retrospectively selected.The children were divided into reference group(n=60)and study group(n=60)according to different anesthesia meth-ods.The reference group was given general anesthesia,and the study group was given brachial plexus block combined with general anesthesia.The hemodynamic indexes,stress response and inflammatory factor levels were compared be-tween the two groups.Results There were no significant differences in heart rate and mean arterial pressure between the reference group and the study group at T0(before anaesthetic)(both P>0.05).At T1(When placing a laryngeal mask)and T2(When removing a laryngeal mask),the level of heart rate and mean arterial pressure in the study group were smaller than those in the reference group,and the differences were statistically significant(all P<0.05).There was no significant difference in stress response index between the reference group and the study group at 5 min before operation(P>0.05).The level of cortisol,epinephrine and norepinephrine in the study group were lower than those in the reference group at 6 h after operation,and the differences were statistically significant(all P<0.05).There were no significant differences in the levels of inflammatory factors between the reference group and the study group before op-eration(all P>0.05).The changes of tumor necrosis factor-α(26.01±5.34)ng/L,C-reactive protein(8.71±1.25)mg/L and interleukin-1β(2.03±0.34)ng/L in the study group were lower than those in the reference group at 3 days after operation,and the differences were statistically significant(t=12.865,11.849,18.676,all P<0.05).Conclusion Bra-chial plexus block combined with general anesthesia can reduce the stress response,less inflammatory reaction,and less hemodynamic level fluctuation.
Upper limb fracture in childrenBrachial plexus blockGeneral anesthesiaStress responseInflammatory factor
NETL
NSTL
万方数据
