Effects of Bifidobacterium Bifidum Triplex Combined with Hepatoprotec-tive Therapy on Serum Inflammatory Factor Levels and Intestinal Flora in Patients with Hepatitis B Cirrhosis
Objective To analyze the effect of simultaneous combination of bifidobacterium bifidum triplex and hepa-toprotective therapy in the treatment of hepatitis B cirrhosis.Methods 92 patients with hepatitis B cirrhosis admitted to the First Affiliated Hospital of Hainan Medical College from March 2020 to March 2023 were selected as the study subjects,and they were divided into the control group and the observation group after generating a randomized se-quence using the latest statistical software,with 46 cases each.The control group was treated with hepatoprotective therapy,and the observation group was treated with hepatoprotective therapy simultaneously combined with bifidobac-terium bifidum triplex.The level of intestinal flora,inflammatory factors and quality of life before and after treatment in the two groups were compared.Results Bifidobacterium bifidum,Lactobacillus and Bacteroides anomalies in the in-testinal tract of the observation group were higher than those of the control group,the differences were statistically sig-nificant(all P＜0.05),and yeast-like fungi(2.84±0.49)CFU/g was lower than that of the control group,and the differ-ence was statistically significant(t=7.720,P＜0.05).The levels of various inflammatory factors in the observation group were lower than those in the control group,and the differences were statistically significant(all P＜0.05).The scores of physical health,mental health,social relationship and environment in the observation group were higher than those in the control group,and the differences were statistically significant(all P＜0.05).Conclusion For patients with hepatitis B cirrhosis,taking bifidobacterium bifidum triplex combined with hepatoprotective therapy is conducive to improving the probiotic environment in the intestinal tract,decreasing its inflammatory response,and leading to a steady improve-ment in the quality of life of the patients,which is worthy of further study.
Hepatitis B cirrhosisBifidobacterium bifidum triplexHepatoprotective therapySerum inflammatory factorIntestinal floraQuality of life
NETL
NSTL
万方数据
