Effects of Astragaloside on Oxidative Stress and Airway Remodeling in Rats with Chronic Obstructive Pulmonary Disease
Objective To investigate the effects of astragaloside on oxidative stress and airway remodeling in chronic obstructive pulmonary disease(COPD)rats.Methods Seventy SD rats were selected and divided into normal group,model group,N-acetylcysteine group,dexamethasone group,and low,medium,and high dose astragaloside group by randomized table method,10 rats in each group.The rats in the normal group were not treated in any way.The COPD rat model was prepared by smoking,and the treatment group was given N-acetylcysteine,dexamethasone,and astraga-loside interventions,respectively.24 weeks later,changes in lung function,oxidative stress and airway remodeling-related indexes were detected in the rats.Results Compared with the model group,lung function-related indexes,se-rum cytokines,alveolar lavage cytokines,and oxidative/antioxidant enzymes indexes of rats in the high dose astragalo-side group were significantly better than those of the model group,and the differences were statistically significant(all P<0.05).Conclusion Astragaloside can improve or delay the occurrence of airway remodeling in COPD by scavenging oxygen free radicals and reducing airway inflammation and oxidative stress levels.
万方数据
维普
