Comparison of the Effects of Application of Nadroparin Calcium and So-dium Citrate Anticoagulation in Continuous Renal Replacement Therapy in Patients with Severe Acute Kidney Injury
Objective To compare the difference in anticoagulation effect between nadroparin calcium and sodium ci-trate in continuous renal replacement therapy(CRRT)for patients with severe acute kidney injury(AKI).Methods 80 patients with severe AKI admitted to the Department of Critical Care Medicine of Xuzhou Jiawang District People's Hospital during from 2022 to December 2023 were purposefully selected as the study objects,and were divided into the control group(treated with nadroparin calcium)and the observation group(treated with sodium citrate)according to different treatment methods,with 40 cases in each group.The anticoagulation effect,coagulation,renal function re-covery and complications of the two groups were compared.Results The anticoagulation effective rate of the observa-tion group(95.00%)was higher than that of the control group(75.00%),and the complication rate of the observation group(7.50%)was lower than that of the control group(30.00%),and the differences were statistically significant(χ2=6.275,6.646,both P<0.05).After treatment,the activated partial thromboplastin time of patients in the observation group was longer than that of the control group,the creatinine clearance rate was higher than that of the control group,and the fibrinogen,D-dimer,urea nitrogen,and blood creatinine were lower than those of the control group,the differ-ences were statistically significant(all P<0.05).Conclusion For patients with severe AKI,the anticoagulant effect of nadroparin calcium in CRRT treatment is better than that of sodium citrate,and its value in improving coagulation function is outstanding,which has a positive impact on the recovery of renal function of patients,and can reduce the risk of complications.
Severe acute kidney injuryContinuous renal replacement therapyNadroparin calciumSodium citrate anticoagulationCoagulation indexRenal function
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