首页|丁苯酞氯化钠联合奥扎格雷钠治疗急性脑梗死患者的临床效果

丁苯酞氯化钠联合奥扎格雷钠治疗急性脑梗死患者的临床效果

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目的 分析丁苯酞氯化钠联合奥扎格雷钠治疗急性脑梗死患者的临床效果.方法 非随机选取2021年5月—2023年5月淮安市楚州中医院收治的128例急性脑梗死患者为研究对象,根据治疗药物不同将患者分为两组,每组64例.对照组给予奥扎格雷钠注射液治疗,研究组在对照组基础上给予丁苯酞氯化钠注射液.对比观察两组患者临床疗效、凝血指标、不良反应发生情况.结果 研究组总有效率(95.31%)高于对照组(82.81%),差异有统计学意义(χ2=5.133,P<0.05);治疗后,研究组活化部分凝血酶时间、凝血酶原时间、国际标准化比值高于对照组,纤维蛋白原水平低于对照组,差异有统计学意义(P均<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05).结论 急性脑梗死患者应用丁苯酞氯化钠联合奥扎格雷钠治疗能够提高临床疗效,且有助于改善凝血功能,且不会增加不良反应风险,安全性较高.
Clinical Effect of Sodium Butylphthalein Chloride Combined with Sodium Ozagrel on Patients with Acute Cerebral Infarction
Objective To analyze the clinical effect of sodium butylphthalein chloride combined with sodium ozagrel on patients with acute cerebral infarction.Methods A total of 128 patients with acute cerebral infarction admitted in Chuzhou Hospital of Traditional Chinese Medicine of Huai'an City from May 2021 to May 2023 were non-randomly selected as study objects and divided into two groups according to different therapeutic drugs,with 64 patients in each group.The control group was given sodium ozagrel injection,and the study group was given sodium chloride bu-tylphthalein injection on the basis of the control group.The clinical efficacy,coagulation index and occurrence of ad-verse reactions were compared and observed between the two groups.Results The total effective rate of the study group(95.31%)was higher than that of the control group(82.81%),and the difference was statistically significant(χ2=5.133,P<0.05).After treatment,the activated partial thrombin time,prothrombin time and international standardized ratio of the study group were higher than those of the control group,and the fibrinogen level was lower than that of the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the inci-dence of adverse reactions between the two groups(P>0.05).Conclusion The application of sodium butylphthalein chloride combined with sodium ozagrel in the treatment of acute cerebral infarction can improve clinical efficacy,and help to improve coagulation function,at the same time,does not increase the risk of adverse reactions,and has high safety.

Butylphthalein sodium chlorideSodium ozagrelAcute cerebral infarctionClinical effectCoagulation indexAdverse reaction

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淮安市楚州中医院神经内科,江苏 淮安 223200

丁苯酞氯化钠 奥扎格雷钠 急性脑梗死 临床疗效 凝血指标 不良反应

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(12)
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