Analysis of The Diagnostic Value of Abnormal Prothrombin Ⅱ and Alpha-fetoprotein Combined Detection in Primary Liver Cancer
Objective To analyze the value of abnormal prothrombin Ⅱ+alpha-fetoprotein combined detection in the diagnosis of primary liver cancer.Methods 180 patients with liver disease treated in the Sixth People's Hospital of Qingdao from January 2021 to October 2022 were purposefully selected as the study objects,including 60 patients with primary hepatic carcinoma(HCC group)and 60 patients with hepatitis(hepatitis group)and 60 patients with cir-rhosis(cirrhosis group).Abnormal prothrombin Ⅱ(PIVKA-Ⅱ)and alpha fetoprotein(AFP)were detected in all pa-tients.The diagnostic efficiency of AFP test,PIVKA-Ⅱ and combined test was analyzed.Results Abnormal prothrom-bin Ⅱ and alpha-fetoprotein in HCC group were higher than those in other two groups,and liver cirrhosis group was higher than chronic hepatitis group,the differences were statistically significant(all P<0.05).The sensitivity of the combined test was 96.66%,specificity 91.66%and accuracy 93.33%,which were significantly higher than AFP test(81.66%,75.00%,77.22%)and PIVKA-Ⅱ test(86.66%,82.50%,83.88%),and the difference were statistically sig-nificant(χ2=6.792,11.882,18.318,all P<0.05).Conclusion Abnormal prothrombin Ⅱ and alpha-fetoprotein levels are higher in patients with primary liver cancer,and the combined detection of abnormal prothrombin Ⅱ and alpha-fetoprotein has higher diagnostic efficacy than single detection,which can improve the sensitivity,specificity and accu-racy of clinical diagnosis.
Abnormal prothrombin ⅡAlpha-fetoproteinPrimary liver cancer
万方数据
维普
