The Correlation and Consistency of Two Chemiluminescence Platforms for Detecting Tumor Markers
Objective To evaluate the correlation and consistency of two chemiluminescence detection systems for de-tecting tumor markers.Methods Tumor markers carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),carbohy-drate antigen 19-9(CA19-9),carbohydrate antigen 15-3(CA153),carbohydrate antigen 12-5(CA125),total prostate specific antigen(t-PSA)and free prostate specific antigen(f-PSA)were detected by Snibe MAGLUMI X3 chemilumi-nescence detection system and Beckman UniCel DXI 800 chemiluminescence detection system,respectively.Accord-ing to the requirements of the American Committee for Clinical Laboratory Standardization EP9-A2 document,the cor-relation and consistency of the results of different instruments and reagents were evaluated by Pearson correlation analysis,regression analysis and Blain-Altman consistency analysis.Results In the reference range of the two detec-tion systems,linear correlation coefficient(r)of AFP,CEA,CA153,CA199,CA125,f-PSA,t-PSA were 0.992,0.984,0.982,0.986,0.992,0.990,0.992(all P<0.001),the two detection systems were significantly correlated.By Passing-Bablok regression analysis,there is a linear relationship between the two detection systems.Bland-Altman analysis showed that the two detection systems had good consistency,the difference amplitude was clinically acceptable,and the results were clinically interchangeable.Conclusion The correlation between the detection of AFP,CEA,CA125,CA199,CA153,t-PSA and f-PSA by Snibe MAGLUMI X3 chemiluminescence immunoanalyzer and Beckman UniCel DXI 800 chemiluminescence immunoanalyzer is good.The consistency of the two detection systems is relatively high.
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