Effect of Sodium Valproate Sustained-release Tablets Combined with Ziprasidone Hydrochloride in the Treatment of Bipolar Disorder Manic Episodes
Objective Exploring the therapeutic effect of the combination of ziprasidone hydrochloride and sodium val-proate controlled-release tablets in the treatment of bipolar disorder manic episodes.Methods A total of 66 patients with bipolar disorder manic episodes admitted to Qufu Mental Disease Prevention and Treatment Hospital from Octo-ber 2022 to October 2023 were non-randomly selected as the research objects.They were divided into two groups by different treatment methods,with 33 cases in each group.The reference group was treated with sodium valproate sustained-release tablets,while the study group was treated with sodium valproate sustained-release tablets combined with ziprasidone hydrochloride.The therapeutic effects of two groups were compared.Results There was no statisti-cally significant difference in the Beck Raphaelsen Mania Rating Scale(BRMS)score between the two groups before and 1 week after treatment(both P>0.05).After 4 weeks of treatment and 8 weeks of treatment,the scores of the study group were lower than that of the control group,and the differences were statistically significant(both P>0.05).The time of Trail Making Test(TMT)A and TMT B of the study group were both shorter,and the differences were statisti-cally significant(both P>0.05).The Treatment Emergency Symptom Scale(TESS)score of the study group was 1.62±0.35,which was lower than 2.50±0.39 of the control group,and the difference was statistically significant(t=9.646,P<0.05).Conclusion The combination of sodium valproate sustained-release tablets and ziprasidone hydrochloride has a significant effect on the treatment of bipolar disorder manic episodes and can improve the cognitive level of patients.
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