The Effect of Budesofrine Inhalation Aerosol Combined with Theophylline Treatment on the Level of Inflammatory Factors in Patients with COPD in the Stable Stage
Objective To investigate the application value of budesonide inhalation aerosol combined with theophyl-line treatment in patients with chronic obstructive pulmonary disease(COPD)in the stable stage,focusing on analyz-ing the effect of the combined treatment on the level of inflammatory factors.Methods Seventy-two COPD patients in the stable stage admitted to Funing County People's Hospital from March 2022 to November 2023 were objectively se-lected for the study,and were divided into two groups of 36 cases each by difference treatment.The control group was treated with conventional theophylline therapy,and the observation group was treated with budesonide inhalation aero-sol on the basis of the control group,and the two groups were compared in terms of interleukin(IL)-8,IL-10,peak ex-piratory flow(PEF),forced vital capacity(FVC),health and quality of life,health status and quality of life,and adverse effects.Results The IL-8 of the observation group was lower than that of the control group,and the IL-10 was higher than that of the control group,and the differences were statistically significant(both P<0.05).The levels of FVC and PEF in the observation group were higher than those in the control group,and the scores of health status and quality of life were lower than those in the control group,and the differences were statistically significant(all P<0.05).The inci-dence of adverse reactions between the two groups(11.11%vs 8.33%)were compared,the difference was not statisti-cally significant(χ2=0.158,P>0.05).Conclusion In the stable period of COPD,the combination of budesonide inhala-tion aerosol and theophylline extended-release tablets can improve the level of inflammatory factors,health status and quality of life of patients,and promote the recovery of lung function,and the safety of the medication is good.
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