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结核潜伏感染者筛选和免疫预防治疗研究进展

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现阶段,结核分枝杆菌(Mycobacterium Tuberculosis,MTB)潜伏感染筛选与免疫预防存在诸多限制因素,取得的效果仍有不足,这些因素均会对结核病防控产生一定的影响.然而,灵敏度、特异度更高的筛查方式,以及高效且持久的免疫预防疫苗、简化的用药治疗方案正处于研发与观察阶段,现已成为结核病防控工作的研究重点,同时也给MTB潜伏感染者带来了更多的希望.本文针对MTB潜伏感染者的筛选现状,以及免疫预防研究成果进行综述,分析各项筛查方法的优劣,以及最新的预防与治疗研发动态,以便明确此群体防控工作的进展情况,为基层医院筛选和防治结核病提供一定的参考.
Research Progress in Screening and Immunoprophylactic Treatment of La-tent Tuberculosis Infections
At the present stage,there were many limiting factors in the screening of Mycobacterium tuberculosis(MTB)latent infection and immunoprophylaxis,and the results were still insufficient.These factors would have a cer-tain impact on the prevention and control of tuberculosis.However,screening methods with higher sensitivity and specificity,as well as efficient and lasting immune prevention vaccines and simplified drug treatment schemes are in the stage of development and observation,which have become the research focus of tuberculosis prevention and con-trol,and also bring more hope to people with latent infection of MTB.This article reviews the screening status of latent infection of MTB and the research results of immune prevention,analyzes the advantages and disadvantages of various screening methods,as well as the latest research and development trends of prevention and treatment,in order to clarify the progress of prevention and control of this group,and provide some reference for the screening and treatment of tuberculosis in basic hospitals.

Latent infection of tuberculosisScreeningImmunoprophylactic therapyResearch progress

刘清文

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山东省菏泽市传染病医院检验科,山东 菏泽 274000

结核潜伏感染 筛选 免疫预防治疗 研究进展

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(13)