首页|哌拉西林钠他唑巴坦钠注射剂联合注射用地塞米松磷酸钠治疗社区获得性肺炎伴发热的临床研究

哌拉西林钠他唑巴坦钠注射剂联合注射用地塞米松磷酸钠治疗社区获得性肺炎伴发热的临床研究

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目的 探讨伴发热的社区获得性肺炎患者联用哌拉西林钠他唑巴坦钠与地塞米松的治疗效果.方法 目的选取2020年2月—2023年10月扬州洪泉医院诊治的社区获得性肺炎者伴发热86例,按照给药方式不同分为对照组和观察组,每组43例.对照组予哌拉西林钠他唑巴坦钠治疗,观察组再加地塞米松治疗,比较患者治疗效果、症状改善时间、炎性因子水平与不良反应.结果 观察组临床有效率为95.35%(41/43),较对照组的79.07%(34/43)高,差异有统计学意义(χ2=5.108,P<0.05).观察组治疗后的各症状改善时间、炎性因子水平均低于对照组,差异有统计学意义(P均<0.05).两组不良反应率对比,差异无统计学意义(P>0.05).结论 伴发热的社区获得性肺炎结合哌拉西林钠他唑巴坦钠、地塞米松治疗效果可靠,症状改善效果较好且可降低炎症反应.
Effectiveness of Combining Piperacillin Sodium Tazobactam Sodium and Dexamethasone in the Treatment of Community-Acquired Pneumonia with Fever
Objective To explore the efficacy of combination therapy with piperacillin sodium tazobactam sodium and dexamethasone in patients with community-acquired pneumonia with fever.Methods A total of 86 community-acquired pneumoniafrom patients with fever in Hongquan Hospital of Yangzhou from February 2020 to October 2010 were obiectively selected.They were grouped by thethe different administration methods,they were divided into con-trol group and observation group,with 43 cases in each group.In the control group,piperacillin sodium taazobactam sodium injection,the observation group added dexamethasone injection,to compare the treatment effect,time to symp-tom improvement,level of inflammatory factors and adverse effects.Results Higher efficacy rate in the observation group was 95.35%(41/43)was higher compared to the control group 79.07%(34/43),the difference was statistically significant(χ2=5.108,P<0.05).The improvement time of various symptoms and levels of inflammatory factors in the observation group after treatment were lower than those in the control group,the differences were statistically signifi-cant(all P<0.05).There was no statistically significant difference in the adverse reaction rate ratio between the two groups(P>0.05).Conclusion The addition of dexamethasone to piperacillin sodium tazobactam sodium therapy in pa-tients with community-acquired pneumonia associated with fever improves the therapeutic and reduces the inflamma-tory response,and is worthy of promotion.

Community-acquired pneumoniaFeverPiperacillin sodium tazobactam sodiumDexamethasoneInflammatory factor levels

戴明娟、刘林、刘梦

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扬州洪泉医院药剂科,江苏 江都 225200

社区获得性肺炎 发热 哌拉西林钠他唑巴坦钠 地塞米松 炎性因子水平

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(14)