Research Progress on miRNAs and Their Single Nucleotide Polymor-phisms in Ischemic Stroke
Ischemic stroke(IS)is a multifactorial disease caused by the combined effects of environmental and ge-netic factors.Its genetic susceptibility and the mechanism of ischemic brain injury are still hot research topics in re-cent years.Abnormal expression profiles of microRNAs(miRNAs)are involved in multiple processes such as the etiol-ogy,pathophysiology,neuroprotection,and post-stroke brain edema of ischemic stroke.Single nucleotide polymor-phism(SNP)refers to the DNA sequence polymorphism caused by the transposition,transformation,insertion,deletion of a single nucleotide on a DNA fragment.When miRNA has SNP,it may directly or indirectly affect the expression of its target genes,thereby affecting the occurrence and development of IS.Therefore,the SNP of miRNA can become a new entry point for studying the interaction between miRNA and IS.This article aims to review the relationship be-tween some miRNAs and their SNPs with IS,in order to provide scientific basis for the diagnosis,treatment,and prog-nosis evaluation of IS.
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