The Effect of Ultra Early Small Bone Window Minimally Invasive Surgery on VEGF,Ang-1,and Neurological Indicators in Hypertensive Intracere-bral Hemorrhage
Objective To investigate the treatment of hypertensive intracerebral hemorrhage by ultra-early microinci-sion with small bone window The efficacy of HICH and its effect on the patients with vascular endothelial growth fac-tor(VEGF),angiopoietin-1(Ang-1),and nerve function were reported.Methods 90 patients with HICH admitted to Qihe County People's Hospital from January 2022 to May 2023 were non-randomly selected as the study subjects,and divided into ultra-early group(n=45)and early group(n=45)according to different onset times.Patients in both groups were treated with small bone window microsurgery,the early group was operated on 6-12 hours after onset,and the ultra-early group was operated on 6 hours after onset.The therapeutic effect of the two groups was com-pared.Results The total effective rate of the super early group was 95.56% (43/45),which was higher than 80.00% (36/45)of the early group,and the difference was statistically significant(χ2=5.074,P=0.024).The levels of VEGF,Ang-1 and neuron-specific enolase in super early group were lower than those in early group 3 days after surgery,and the levels of brain-derived neurotrophic factor were higher than those in early group,and the differeces were sta-tistically significant(all P<0.05).The total complication rate of super early group was lower than that of early group,and the difference was statistically significant(P<0.05).Conclusion The effect of ultra-early small bone window mi-crosurgery in the treatment of HICH is satisfactory,the levels of serum VEGF and Ang-1 are reduced,the neurologi-cal function indexes are improved,and the incidence of postoperative complications is low.
Hypertensive cerebral hemorrhageUltra-early microincision of small bone windowCurative effectVascular endothelial growth factorAngiopoietin-1Neural function index
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