首页|双歧杆菌三联活菌在非酒精性脂肪性肝病患者中临床应用价值分析

双歧杆菌三联活菌在非酒精性脂肪性肝病患者中临床应用价值分析

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目的 探究非酒精性脂肪性肝病患者接受双歧杆菌三联活菌治疗价值.方法 非随机选取2022年3月—2024年2月海南医学院第一附属医院收治的84例非酒精性脂肪性肝病患者为研究对象,根据治疗方式不同分为对照组及观察组,各42例.对照组采用多烯磷脂酰胆碱,观察组采用双歧杆菌三联活菌.对比肝功能、肠道菌群及炎性因子水平.结果 治疗前,两组患者肝功能指标、肠道菌群及炎性因子水平对比,差异无统计学意义(P均>0.05);治疗后,观察组患者谷草转氨酶为(28.49±5.68)U/L、总胆红素为(8.99±1.44)mmol/L、谷丙转氨酶为(28.87±5.91)U/L,均低于对照组的(31.58±4.67)U/L、(10.02±1.57)mmol/L、(33.17±5.86)U/L,差异有统计学意义(t=2.723、3.133、3.348,P均<0.05);治疗后,观察组肠道菌群及炎性因子水平均优于对照组,差异有统计学意义(P均<0.05).结论 双歧杆菌三联活菌对肝功能指标影响显著,降低炎症因子对肠道及肝脏影响,并恢复肠道菌群.
Analysis of Clinical Application Value of Bifidobacteria Trivialis in Pa-tients with Nonalcoholic Fatty Liver Disease
Objective To explore the therapeutic value of bifidobacterium triple live bacteria in patients with non-alcoholic fatty liver disease.Methods A total of eighty-four patients with nonalcoholic fatty liver disease admitted to the First Affiliated Hospital of Hainan Medical College from March 2022 to February 2024 were non-randomly se-lected as the study objects,and were divided into control group and observation group according to different treatment methods,with forty-two cases in each group.The control group was treated with polyene phosphatidylcholine,and the observation group was treated with bifidobacterium triad.Liver function,intestinal flora and inflammatory factors were compared.Results Before treatment,there were no significant differences in liver function indexes,intestinal flora and inflammatory factors between 2 groups(all P>0.05).After treatment,the glutamic oxalic transaminase,total bilirubin and alanine transaminase in observation group were(28.49±5.68)U/L,(8.99±1.44)mmol/L and(28.87±5.91)U/L,it was lower than(31.58±4.67)U/L,(10.02±1.57)mmol/L,(33.17±5.86)U/L in control group,and the differences were statistically significant(t=2.723,3.133,3.348,all P<0.05).After treatment,the levels of intestinal flora and inflamma-tory factors in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Bifidobacteria triple live bacteria can significantly improve the liver function in-dex of patients,reduce the impact of inflammatory factors on the intestine and liver,and restore intestinal flora.

Bifidobacterium trivialisNonalcoholic fatty liver diseaseLiver functionIntestinal floraInterleukin-6Enterobacter

李艳芬、史键山、罗秋娜、孙龙

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海南医学院第一附属医院感染科,海南 海口 570102

海南医学院第一附属医院介入血管外科,海南 海口 570102

双歧杆菌三联活菌 非酒精性脂肪性肝病 肝功能 肠道菌群 白细胞介素-6 肠杆菌

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(15)