Analysis of Anticoagulant Treatment Effect of Naphtholimus Mesylate on High Bleeding Risk Blood Purification Patients
Objective To study the anticoagulation effect of naproxat mesylate in patients with high blood risk blood purification.Methods seventy patients with high blood risk of blood purification admitted to Jingmen People's Hospi-tal from July to December 2023 were non-randomly selected as the study objects,and were divided into control group and observation group according to treatment methods,with thirty-five cases in each group.The control group was given 4% sodium citrate for anticoagulation,and the observation group was given napathmostat mesylate for anticoagu-lation.Results Before treatment,there was no significant difference in laboratory indexes between the two groups(P>0.05).After treatment,plasma prothrombin time,thrombin time and partial thrombin time in observation group were shortened compared with control group,and the differences were statistically significant(all P<0.05).The classifica-tion of coagulation status of tubes and dialyzers in observation group was better than that in control group,the differ-ence was statistically significant(P<0.05).The average life of the filter in the observation group was longer than that in the control group,the difference was statistically significant(P<0.05).The complication rate of the observation group was 5.71% (2/35),which was lower than 22.86% (8/35)of the control group,and the difference was statistically signifi-cant(χ2=4.200,P<0.05).Conclusion Naproxat mesylate can reduce the risk of blood clotting and prolong the life of filter in patients with high risk of bleeding.
Blood purificationHigh risk of bleedingCoagulation functionNaphtholimus mesylateSodium citrateHemorrhagic complications
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