Comparison of Efficacy of Levetiracetam and Sodium Valproate Tablets in the Treatment of Primary Focal Epilepsy
Objective To investigate the clinical effect of levetiracetam and sodium valproate tablets in the treatment of primary focal epilepsy.Methods Seventy-six patients with primary focal epilepsy admitted to the Department of Neurology of Xuzhou Municipal Hospital affiliated to Xuzhou Medical University from January 2021 to January 2024 were non-randomly selected and divided into control group and observation group according to the treatment method,thirty-eight cases each.The control group was treated with sodium valproate,and the observation group was treated with levetiracetam.The two groups were compared in terms of overall efficacy rate,incidence of adverse effects,serum neuron-specific enolase(NSE),homocysteine(HCY),and insulin-like growth factor 1(IGF-1).Results After treat-ment,NSE and HCY of the observation group were lower than those of the control group,and IGF-1 was higher than control group,and the differences were statistically significant(all P<0.05).After treatment,the total effective rate of the observation group was 89.47% (34/38),which was higher than 68.42% (26/38)of the control group,and the differ-ence was statistically significant(χ2=5.067,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with sodium valproate,levetiracetam is efficacious in the treatment of first-episode focal epilepsy and is safe while effectively controlling epileptic discharges of neurons in the brain.
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