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门冬胰岛素治疗妊娠期糖尿病孕妇的临床效果

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目的 分析妊娠期糖尿病孕妇运用门冬胰岛素治疗的价值.方法 回顾性选取2021年12月—2023年12月济宁市兖州区人民医院收治的70例妊娠期糖尿病孕妇的临床资料,按治疗方法分为两组,每组35例.对照组使用生物合成胰岛素治疗,观察组使用门冬胰岛素治疗.比较两组血糖、胰岛素指标、总胆固醇、总胆红素、尿酸、不良妊娠结局发生率.结果 治疗后,观察组糖化血红蛋白(4.69±0.79)%、空腹血糖(4.66±0.61)mmol/L、餐后2 h血糖(7.11±1.56)mmol/L低于对照组的(5.88±1.56)%、(5.79±0.85)mmol/L、(8.44±1.85)mmol/L,差异有统计学意义(t=4.026、6.389、3.251,P均<0.05).观察组胰岛素指标、总胆固醇、总胆红素、尿酸水平优于对照组,差异有统计学意义(P均<0.05).观察组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05).结论 门冬胰岛素在妊娠糖尿病治疗中的效果好,可以改善胰岛β细胞功能,降低不良妊娠结局的发生率.
Clinical Effect of Insulin Aspart on Pregnant Women with Gestational Dia-betes
Objective To analyze the value of treating pregnant women with gestational diabetes mellitus using men-thol insulin.Methods The clinical data of 70 pregnant women with gestational diabetes admitted to Yanzhou District People's Hospital in Jining City from December 2021 to December 2023 were retrospectively selected and divided into two groups according to treatment methods,with 35 cases in each group.The control group was treated with bio-synthetic insulin and the observation group was treated with menthol insulin.The two groups were compared in terms of blood glucose,insulin index,total cholesterol,total bilirubin,uric acid,and the incidence of adverse pregnancy out-comes.Results After treatment,glycated hemoglobin(4.69±0.79)%,fasting plasma glucose(4.66±0.61)mmol/L,and 2 h postprandial plasma glucose(7.11±1.56)mmol/L of the observation group were lower than(5.88±1.56)%,(5.79±0.85)mmol/L,and(8.44±1.85)mmol/L of the control group,and the differences were statistical significance(t=4.026,6.389,3.251,all P<0.05).Insulin index,total cholesterol,total bilirubin,and uric acid levels in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The inci-dence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the differ-ence was statistically significant(P<0.05).Conclusion Mentholated insulin is efficacious in the treatment of gesta-tional diabetes mellitus,improving pancreatic β-cell function and reducing the incidence of adverse pregnancy out-comes.

Gestational diabetesAspartate insulinInsulin indicatorsAdverse pregnancy outcomes

徐瑞、张峰

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济宁市兖州区人民医院产科,山东 济宁 272100

济宁市兖州区人民医院创伤外科,山东 济宁 272100

妊娠期糖尿病 门冬胰岛素 胰岛素指标 不良妊娠结局

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(15)