Effects of Epalrestat Capsule Combined with Alprostadil Injection on Vas-cular Elasticity and Inflammatory Factors in Patients with Diabetes Foot
Objective To analyze the therapeutic effect of epalrestat capsule combined with alprostadil injection in pa-tients with diabetes foot,and its effect on vascular elasticity and inflammatory factors.Methods Eighty patients with diabetes foot who were admitted to the Zibo Hospital of Peking University Medical College from January 2022 to Octo-ber 2023 were selected as the research objects by target sampling method.According to the different treatment meth-ods,they were divided into the control group and the observation group,with forty cases in each group.The control group was treated with single drug injection of alprostadil,while the observation group was treated with a combination of epalvestat capsule and alprostadil injection.The treatment effects,hemodynamic indicators,inflammatory factor lev-els,clinical symptom scores,and vascular elasticity were compared between the two groups.Results The total effec-tive rate of the observation group was 90.00%(36/40),which was higher than the control group's 70.00%(28/40),and the difference was statistically significant(χ2=5.000,P<0.05).After treatment,the pulsatility index,vascular diameter,and blood flow velocity of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).The levels of high-sensitivity C-reactive protein,interleukin 6,and tumor necro-sis factor alpha in the observation group were lower than those in the control group,and the differences were statisti-cally significant(all P<0.05).The symptom scores of claudication,foot swelling,and foot pain in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The degree of vascular elasticity in the observation group was higher than that in the control group,and the difference was statisti-cally significant(P<0.05).Conclusion The treatment of epalrestat combined with alprostadil in patients with diabetes foot can effectively improve the hemodynamic indexes and inflammatory status of the patients,and enhance the vascu-lar elasticity,which has high application value.
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