Non-invasive Prenatal Genetic Testing Technology for the Detection and Analysis of Fetal Chromosomal Aneuploidy Abnormalities at High Risk
Objective To analyze the detection of high risk of fetal chromosome aneuploidy by non-invasive prenatal gene detection technology.Methods A total of 1 257 pregnant women who underwent amniotic fluid karyotype exami-nation in Tai'an Central Hospital from May 2023 to January 2024 were non-randomly selected as the study objects.Non-invasive prenatal genetic testing technology was applied to examine the results of noninvasive prenatal genetic testing technology and the detected number of various sex chromosome abnormalities,and the analysis of chromosome karyotype in amniotic fluid was taken as the gold standard.The coincidence rate of non-invasive prenatal genetic test-ing was analyzed.Results Taking the karyotype of amniotic fluid as an example,18 cases were positive and 1 239 cases were negative.The diagnostic accuracy,sensitivity and specificity of noninvasive prenatal genetic testing were 99.84%(1 255/1 257),88.89%(16/18),100.00%(1 239/1 239),and the Kappa value of chromosome karyotype with amniotic fluid was 0.940.Conclusion Non-invasive prenatal gene detection technology has high accuracy and reliabil-ity in screening such abnormalities,which can help medical staff find possible fetal abnormalities earlier,and give par-ents and doctors more time to make decisions and make psychological preparations.
NETL
NSTL
万方数据
