Analysis of the Efficacy and Safety of Radiotherapy Combined with Immu-notherapy in Locally Advanced Non-small Cell Lung Cancer
Objective To analyze the objective response rate and safety of radiotherapy combined with immunotherapy for advanced Non-small cell lung cancer(NSCLC).Methods The clinical date of sixty-six inoperable patients with lo-cally advanced NSCLC admitted to the Oncology Department of the Sixth Division Hospital of Xinjiang Production and Construction Corps from November 2022 to November 2023 were retrospectively selected.According to different treat-ment regiments,thirty-three patients with local advanced NSCLC treated with radiotherapy combined with immuno-therapy were selected as the observation group and thirty-three patients treated with radiotherapy were selected as the control group.Objective response rate and safety were compared between the two groups.Results The objective remis-sion rate in the observation group was 48.48%(16/33),which was higher than 21.21%(7/33)in the control group,the difference was statistically significant(χ2=5.406,P<0.05).There was no statistically significant difference in the inci-dence of adverse reactions between the two groups(P>0.05).Before treatment,serum tumor marker,quality of life score,quality of life score and immune function index level were compared between the two groups,and the difference was not statistically significant(P>0.05).After treatment,the above indexes were improved compared with those be-fore treatment,and the observation group was superior to the control group,the differences were statistically significant(all P<0.05).Conclusion Radiotherapy combined with immunotherapy for advanced NSCLC is both effective and safe,and can reduce the expression level of serum tumor factors,improve the immune function of patients,and improve the survival and quality of life of patients.
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