Evaluation of the Effect of Nimotuzumab Combined with Radiotherapy on Improving the Prognosis of Elderly Patients with Esophageal Squamous Cell Carcinoma
Objective To explore the effect of nimotuzumab combined with radiotherapy on improving the prognosis of elderly patients with esophageal squamous cell carcinoma.Methods Ninety-two cases of elderly esophageal squamous carcinoma patients admitted to Tengzhou Central People's Hospital from January 2018 to June 2021 were non-randomly selected as study subjects.They were divided into two groups according to treatment methods,with 46 cases in each group.The control group was given radiation therapy,while the observation group was combined with nitu-zumab treatment,compared the efficacy,immune indexes,tumor markers,survival rate and adverse reactions of the two groups.Results The tumor control rate of the observation group was 54.35%(25/46),which was higher than 30.43%(14/46)of the control group,and the difference was statistically significant(χ2=5.386,P<0.05).The levels of immune indexes and tumor marker indexes in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference between the two groups in adverse reaction(P>0.05).The survival rate of 1 and 2 years after treatment in the observation group were higher than those of the control group,and the differences were statistically significant(both P<0.05).Conclu-sion The application of nituzumab combined with radiation therapy in elderly patients with esophageal squamous car-cinoma may help to improve the immune function,down-regulate the expression level of tumor marker indexes,pro-long the survival period,and have fewer adverse effects.
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