Interleukin 6(IL-6)is the most common inflammatory factor,with anti-inflammatory and pro-inflammatory bidirectional,and plays a huge role in the inflammatory response.Therefore,it is highly expressed in in-flammatory diseases.Lumbar disc herniation can lead to local inflammatory response,resulting in the high expression of IL-6,and the high expression of inflammatory cytokines such as IL-6 can lead to obvious hyperalgesia and partici-pate in the occurrence process of discogenic low back pain and nerve radicalgia.At present,studies have suggested that blocking the IL-6/IL-6R axis can effectively treat inflammation-related autoimmune diseases.It is hoped that by intervening the IL-6 reaction process and blocking the local inflammatory response,disk-derived low back pain and radicular pain can be effectively treated.This article reviews the mechanism of IL-6 inflammation and its effect on lumbar disc herniation,hoping to provide some basis for finding targeted drugs for the treatment of lumbar disc hernia-tion.
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