Analysis of the Influence of Different Proportion of Plasma and Red Blood Cell Infusion on Coagulation Function and Prognosis of Patients with Mas-sive Blood loss
Objective To study and analyze the effect of different proportion of plasma and red blood cell infusion on coagulation function and prognosis of patients with massive blood loss.Methods 140 patients with massive blood loss treated in the Yancheng First Hospital Affiliated of Nanjing University Medicine College(Yancheng first People's Hos-pital)from January 2021 to December 2023 were non-randomly selected as the study subjects.They were divided into group A(n=70)and group B(n=70)by different proportion of infusion.Group A received 100 mL fresh frozen plasma(FFP)∶1 U red blood cell suspension(RBCs),and group B received 100 mL FFP∶1.5 U RBCs.The levels of blood routine indexes[hemoglobin(Hb)and blood platelet(PLT)],infusion volume(FFP,cryoprecipitate,platelets)and co-agulation function indexes[fibrinogen(Fbg),prothrombin time(PT),and activated partial thromboplastin time(APTT)]before and after infusion were compared between the two groups.Results After 24 h infusion,Hb level increased and PLT level decreased in both groups,but group A were higher than group B,the differences were statistically signifi-cant(all P<0.05).The FFP infusion volume in group A was(11.47±0.76)mL/kg,lower than that in group B(17.39±1.38)mL/kg,and the difference was statistically significant(t=31.439,P<0.05).There were no statistically significant differences in the amount of cryoprecipitation and platelet transfusion between the two groups(both P>0.05).After 24 h of infusion,Fbg levels in both groups were decreased,but group A were higher than group B,the levels of PT and aPTT were increased in both groups,but group A were lower than group B,the differences were statistically significant(all P<0.05).Conclusion The 1∶1 infusion ratio of plasma to red blood cell can improve the routine blood of patients with massive blood loss rapidly,have less influence on coagulation function,and reduce the amount of plasma infu-sion.
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