Effect analysis of Sacubitril Valsartan Sodium Tablets Combined with Metoprolol Succinate Extended-release Tablets in the Treatment of Di-lated Cardiomyopathy
Objective To study the effect of sacubitril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets in the treatment of dilated cardiomyopathy(DCM).Methods A total of 118 patients with DCM admitted to Yancheng First People's Hospital from December 2021 to December 2023 were objectively selected and divided into observation group(sacubitril valsartan sodium tablets+metoprolol succinate sustained-release tab-lets)and control group(metoprolol succinate sustained-release tablets alone)according to different drug,with fifty nine cases in each group.The efficacy,myocardial injury,left ventricular function and exercise tolerance of the two groups were compared.Results The total effective rate of the observation group was 96.61% (57/59),which was higher than 84.75%(50/59)of the control group,and the difference was statistically significant(χ2=4.912,P<0.05).After treatment,the myocardial injury in the observation group was lower than that in the control group,and the differences were statistically significant(all P<0.05).The left ventricular ejection fraction of the observation group was higher than that of the control group,and the left ventricular end-diastolic volume,left ventricular end-systolic volume and left atrial diameter were lower than those of the control group,the differences were statistically significant(all P<0.05).The exercise tolerance of the observation group was higher than that of the control group,and the differences were sta-tistically significant(all P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of DCM with sacu-bitril valsartan sodium tablets combined with metoprolol succinate sustained-release tablets can effectively improve the myocardial injury,cardiac function and exercise tolerance of patients,reduce the incidence of adverse reactions,and the curative effect is better.
万方数据
维普
