Effect of Minimally Invasive Neuroendoscopic Surgery on Serum BDNF,TNF-α and MMP-9 Levels in Patients with Hypertensive Cerebral Hem-orrhage
Objective To explore the impact of neuroendoscopic minimally invasive surgery on the levels of brain-derived neurotrophic factor(BDNF),tumor necrosis factor-α(TNF-α),and matrix metalloproteinase-9(MMP9)in pa-tients with hypertensive intracerebral hemorrhage(HICH).Methods 104 HICH patients admitted to Qihe County People's Hospital from January 2022 to March 2023 were non-randomly selected as the research subjects,and were divided into an observation group and a control group according to different treatment methods,with 52 cases in each group.The control group underwent small bone window craniotomy microscopy treatment,while the observation group underwent neuroendoscopic minimally invasive treatment.Compare the perioperative index,serum indicators,and inci-dence of complications between two groups.Results Compared with the control group,the observation group had a shorter surgical time,less surgical bleeding,and a higher hematoma clearance rate,the differences were statistically significant(all P<0.05).5 d after surgery,the serum BDNF levels in the observation group(33.02±3.16)μg/L was higher than that in the control group(28.04±3.29)μg/L,and the difference was statistically significant(t=10.915,P<0.05);the levels of TNF-α and MMP9 in the observation group were lower than those in the control group,and the dif-ferences were statistically significant(both P<0.05).The incidence of postoperative complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of minimally invasive surgery under neuroendoscopy for the treatment of HICH is more effective,sig-nificantly increasing BDNF levels and downregulating TNF-α and MMP9 levels,with a lower incidence of postopera-tive complications.
万方数据
维普
