Effect of Low Dose Methylprednisolone Sodium Succinate Combined with Azithromycin on Children with Severe Mycoplasma Pneumonia
Objective To investigate the value of azithromycin and low dose(2 mg/kg)methylprednisolone sodium suc-cinate in children with severe mycoplasma pneumonia.Methods 100 children with severe mycoplasma pneumonia treated in Xinyi People's Hospital from January 2022 to December 2023 were non-randomly selected as the study ob-jects,and were divided into control group and combination group according to different treatment methods,with 50 cases in each group.The control group was treated with azithromycin,and the combination group was supplemented with a small dose(2 mg/kg)of methylprednisolone sodium succinate.The improvement time of the two groups was com-pared.Serum inflammatory markers[interleukin 6(IL-6),C-reactive protein(CRP),interleukin 8(IL-8)]and immune markers.Results The time of white blood cell count,body temperature,cough relief,lung rales disappearance and lung shadow disappearance in combination group were shorter than those in control group,and the differences were statistically significant(all P<0.05).In the combined group,IL-6 was(17.15±2.16)ng/L,CRP was(13.48±3.64)mg/L and IL-8 was(24.81±2.94)pg/mL,it was better than(20.23±2.79)ng/L,(18.25±4.37)mg/L,(29.27±3.30)pg/mL in the control group,and the differences were statistically significant(t=6.172,5.930,7.136,all P<0.05).The immune indexes of the combined group were lower than those of the control group,and the differences were statistically signifi-cant(all P<0.05).Conclusion The combination of methylprednisolone sodium succinate and azithromycin in children with severe mycoplasma pneumonia can accelerate the improvement of the disease,reduce the inflammatory response,and promote the improvement of immune function.
万方数据
维普
