系统医学2024,Vol.9Issue(17) :169-172.DOI:10.19368/j.cnki.2096-1782.2024.17.169

罗哌卡因联合艾司氯胺酮在硬膜外分娩镇痛中的应用效果与安全性研究:一项随机对照试验

Efficacy and Safety of Popivacaine Combined with Esketamine in Epidural Labor Analgesia:A Randomized Controlled Trial

李继成 刘丹丹 周海峰 骆习珍 李泽龙
系统医学2024,Vol.9Issue(17) :169-172.DOI:10.19368/j.cnki.2096-1782.2024.17.169

罗哌卡因联合艾司氯胺酮在硬膜外分娩镇痛中的应用效果与安全性研究:一项随机对照试验

Efficacy and Safety of Popivacaine Combined with Esketamine in Epidural Labor Analgesia:A Randomized Controlled Trial

李继成 1刘丹丹 1周海峰 1骆习珍 1李泽龙1
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作者信息

  • 1. 孝感市妇幼保健院麻醉科,湖北 孝感 432100
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摘要

目的 评估罗哌卡因联合艾司氯胺酮在硬膜外分娩镇痛中的应用效果与安全性,为临床分娩镇痛提供新的选择.方法 选取2023年1-12月在孝感市妇幼保健院分娩的160例产妇,采用不同麻醉方式分组,每组80例.对照组接受罗哌卡因+舒芬太尼麻醉镇痛,观察组接受罗哌卡因+艾司氯胺酮麻醉镇痛.对比两组麻醉阻滞情况、镇痛相关指标及并发症发生率.结果 T1~T5时,观察组下肢运动神经阻滞情况轻于对照组,差异有统计学意义(P均<0.05).观察组镇痛起效时间短于对照组,补救镇痛的次数低于对照组,差异有统计学意义(P均<0.05).观察组的并发症发生率 3.75%(3/80)低于对照组的 12.50%(10/80)(χ2=4.103,P<0.05).结论 罗哌卡因联合艾司氯胺酮在硬膜外分娩镇痛中表现出良好的麻醉阻滞效果,对下肢的运动功能影响更小,镇痛起效快,补救镇痛次数少,且并发症发生率低.

Abstract

Objective To evaluate the effect and safety of ropivacaine combined with esketamine in epidural labor an-algesia,and to provide a new choice for clinical labor analgesia.Methods A total of 160 parturients who gave birth in Xiaogan Maternal and Child Health Hospital from January to December 2023 were selected and divided into groups by different anesthesia methods,with 80 cases in each group.The control group received ropivacaine+sufentanil an-esthesia analgesia,and the observation group received ropivacaine+esketamine anesthesia analgesia.The anesthesia block,analgesia related indexes and incidence of complications were compared between the two groups.Results At T1-T5,the motor nerve block of lower limbs in the observation group was lighter than that in the control group,and the difference was statistically significant(all P<0.05).The onset time of analgesia in the observation group was shorter than that in the control group,and the number of remedial analgesia was lower than that in the control group,the differences were statistically significant(both P<0.05).The incidence of complications in the observation group 3.75% (3/80)was lower than that in the control group 12.50%(10/80)(χ2=4.103,P<0.05).Conclusion Ropivacaine combined with esketamine showed good anesthesia block effect in epidural labor analgesia,less influence on the motor function of lower limbs,rapid onset of analgesia,less times of remedial analgesia,and low incidence of complications.

关键词

罗哌卡因/艾司氯胺酮/硬膜外分娩镇痛/麻醉效果/安全性

Key words

Ropivacaine/Esketamine/Epidural labor analgesia/Anesthetic effect/Security

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基金项目

2023年度孝感市自然科学计划拟立项项目(XGKJ2023010029)

出版年

2024
系统医学

系统医学

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