Effect of Concurrent Chemoradiotherapy Combined with Immunotherapy on Adverse Reactions and Effects of Locally Advanced Cervical Cancer Pa-tients
Objective To explore the effect of concurrent chemoradiotherapy combined with immunotherapy on the ad-verse reactions and effects of locally advanced cervical cancer patients.Methods A total of ninety-six patients with lo-cally advanced cervical cancer who received treatment in the Second People's Hospital of Dezhou City from January 2020 to August 2023 were non-randomly selected as the study objects.They were divided into two groups according to different treatment methods,forty-eight cases in each group.The control group received simultaneous chemoradio-therapy,while the study group combined with simultaneous chemoradiotherapy and immunotherapy.Disease control rate,serum tumor markers,cancer-related pain score,cancer-related fatigue score,quality of life score and incidence of adverse reactions were compared between the two groups.Results The disease control rate of the study group was 87.50% (42/48),higher than 68.75%(33/48)of the control group,the difference was statistically significant(χ2=4.937,P<0.05).After treatment,the serum levels of carcinoembryonic antigen,carbohydrate antigen 125 and squamous cell antigen in the study group were lower than those in the control group,the scores of cancer-related pain and cancer-related fatigue in the study group were lower than those in the control group,and the scores of four aspects of quality of life in the study group were higher than those in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Concurrent radiotherapy and chemotherapy combined with immunotherapy can enhance the short-term curative effect of patients with locally advanced cervical cancer,control tumor progression,alleviate cancer-related symptoms,and improve their quality of life,with no increase in adverse reactions,which is safe and reliable.
Locally advanced cervical cancerConcurrent radiotherapy and chemotherapyImmunotherapy
万方数据
维普
