绝经激素治疗对围绝经期女性阴道微生物群落的影响
Effect of Menopausal Hormone Therapy on Vaginal Microflora in Peri-menopausal Women
邓家艳 1王海锋 1李喜荣 1刘丽娥1
作者信息
- 1. 广州中医药大学茂名医院(茂名市中医院)检验科,广东 茂名 525000
- 折叠
摘要
目的 探讨绝经激素治疗对围绝经期女性阴道微生物群落的影响.方法 非随机选取2022年2月—2024年2月广州中医药大学茂名医院收治的120例围绝经期患者为研究对象.按照治疗方式分为观察组和对照组,每组60例.对照组使用谷维素治疗,观察组采用绝经激素治疗.比较两组阴道微生物群落在属水平上的相对丰度、阴道微生态状态、生活质量评分、雌二醇(estradiol,E2)、卵泡刺激素(follicle stimulating hor-mone,FSH).结果 治疗后,观察组阴道微生物群落在属水平优于对照组,差异有统计学意义(P均<0.05).观察组阴道微生态异常率低于对照组,差异有统计学意义(P<0.05).观察组生活质量评分高于对照组,差异有统计学意义(P均<0.05).观察组E2 为(69.58±6.26)ng/L,高于对照组的(64.23±6.19)ng/L,观察组FSH为(23.79±6.71)U/L,低于对照组的(34.88±6.65)U/L,差异有统计学意义(t=4.707、9.093,P均<0.05).结论 绝经激素治疗能够调节围绝经期女性的阴道微生物群落,有助于提高患者的阴道健康状况、激素水平及生活质量.
Abstract
Objective To investigate the effects of menopausal hormone therapy on vaginal microflora in perimeno-pausal women.Methods A total of 120 cases of perimenopausal patients admitted to Maoming Hospital of Guangzhou University of Traditional Chinese Medicine from February 2022 to February 2024 were non-randomly selected as the study subjects.According to the treatment mode,they were divided into observation group and control group,with 60 cases in each group.The control group was treated with ghrelin,and the observation group was treated with meno-pausal hormone.The relative abundance of vaginal microbial communities at the genus level,vaginal microecological status,quality of life scores,estradiol 2(E2)and follicle stimulating hormone(FSH)were compared between the two groups.Results After treatment,the vaginal microbial community in the observation group was better than that in the control group at the genus level,and the differences were statistically significant(all P<0.05).The vaginal microeco-logical abnormality rate of the observation group was lower than that of the control group,and the difference was statis-tically significant(P<0.05).The quality of life score of the observation group was higher than that of the control group,and the differences were statistically significant(all P<0.05).The E2 of the observation group was(69.58±6.26)ng/L,which was higher than(64.23±6.19)ng/L of the control group,and the FSH of the observation group was(23.79±6.71)U/L,which was lower than(34.88±6.65)U/L of the control group,with statistically significant differences(t=4.707,9.093,both P<0.05).Conclusion Menopausal hormone therapy modulates the vaginal microbiota in perimeno-pausal women,helping to improve patients'vaginal health,hormone levels,and quality of life.
关键词
围绝经期女性/绝经激素治疗/阴道微生物群落Key words
Perimenopausal women/Menopausal hormone therapy/Vaginal microbiome引用本文复制引用
出版年
2024
NETL
NSTL
万方数据