The Effects of Temperature on Nausea and Vomiting in Rats were Investi-gated Based on Temperature Monitoring at Different Time Points
Objective To study the effect and mechanism of different temperature on nausea and vomiting in periop-erative rats.Methods Thirty male rats purchased from the Comparative Medicine Center of Mudanjiang Medical Uni-versity in January 2023 were selected and divided into three groups according to the random number table metho,and intraperitoneally injected with cisplatin 3 mg/kg to establish the model of pica.The rats with pica were placed into three groups:room temperature 26°C,humidity 40%-60%(A group);room temperature 23°C,humidity 40%-60%(B group);room temperature 18°C,humidity 40%-60%(C group);at 15 min(T1),2h(T2),4 h(T3),6 h(T4),24 h(T5),the anal temperature,blood pressure,blood gas analysis were measured,and venous blood was collected to isolate plasma for testing the content of arginine vasopressin(AVP)and cortisol concentration.Results The rectal tempera-tures of rats in Groups A,B and C at T2 time point were(36.82±0.08)℃,(36.59±0.12)℃,and(36.22±0.13)℃,respec-tively,the difference was statistically significant(F=72.554,P<0.05).There were also statistically significant differ-ences at T3,T4,and T5 time points,in three groups(all P<0.05);The AVP content in group B exhibited a decrease compared to that in group A at T3 time points,followed by a substantial increase at T5 time points.Meanwhile,the plasma AVP content in group C showed a notable increase at T2 and T4 time points,the differences were statistically significant(all P<0.05);The cortisol concentration in Group B increased at time points T4 and T5,while in Group C,it initially decreased at time point T3,then increased at time point T4 and continued until time point T5,the differ-ences were statistically significant(all P<0.05).Minimal changes in anal temperature,AVP content,and cortisol con-centration were observed in group A within group comparison.Conclusion In the room temperature of 26°C and hu-midity of 40%-60%,the body temperature of rats tends to be more stable,and the changes of plasma AVP content and cortisol concentration are minimal,and the probability of nausea and vomiting is the lowest.
Nausea and vomitingRatsTemperature monitoringArginine vasopressinCortisol
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