首页|眼底激光与雷珠单抗联合治疗糖尿病性黄斑水肿的效果分析

眼底激光与雷珠单抗联合治疗糖尿病性黄斑水肿的效果分析

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目的 分析眼底激光与雷珠单抗联合治疗糖尿病性黄斑水肿(diabetic macular edema,DME)的效果.方法 非随机选取2022年10月—2023年9月曹县人民医院收治的DME患者92例,按治疗方法不同分为两组.对照组46例患者采用眼底激光治疗,研究组46例患者在其基础上联合雷珠单抗治疗.针对两组患者的临床疗效、黄斑水肿改善时间、眼底渗出吸收时间、最佳矫正视力与黄斑中心凹厚度,以及并发症情况进行比较.结果 研究组总有效率95.65%(44/46)相较于对照组80.43%(37/46)更高,差异有统计学意义(χ2=5.060,P<0.05).与对照组相比,研究组黄斑水肿改善时间、眼底渗出吸收时间更短,最佳矫正视力更高,黄斑中心凹厚度更低,差异有统计学意义(P均<0.05).两组并发症发生率对比,差异无统计学意义(P>0.05).结论 眼底激光与雷珠单抗联合治疗DME取得了较为理想的效果,能够有效改善患者的视力水平与黄斑中心凹厚度.
Analysis of the Effect of Retinal Laser Combined with Ranibizumab in the Treatment of Diabetic Macular Edema
Objective To analyze the effect of combining retinal laser and ranibizumab in the treatment of diabetic macular edema(DME).Methods From October 2022 to September 2023,ninety-two DME patients admitted to Caox-ian People's Hospital were non-randomly selected and divided into two groups according to different treatment meth-ods.Forty-six patients in the control group were treated with fundus laser therapy,while forty-six patients in the study group were treated with a combination of ranibizumab on the basis of it.Compare the clinical efficacy,improvement time of macular edema,absorption time of retinal exudate,optimal corrected visual acuity,macular fovea thickness,and complications between two groups of patients.Results The total effective rate in the research group was 95.65%(44/46),higher than 80.43%(37/46)of the control group,and the difference was statistically significant(χ2=5.666,P<0.05).Compared to the control group,the macular edema improvement time and fundus exudate absorption time in the study group were shorter,the best corrected visual acuity was higher,and macular fovea thickness was lower,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in incidence of complications between the two groups(P>0.05).Conclusion The combination of retinal laser and ranibizumab has achieved ideal results in the treatment of DME,which can effectively improve visual acuity and macular fovea thick-ness.

Fundus laserLeizumabDiabetic macular edema

赵华奇

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曹县人民医院眼科,山东 菏泽 274400

眼底激光 雷珠单抗 糖尿病性黄斑水肿

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(22)