布地格福吸入气雾剂与噻托溴铵联合福莫特罗治疗慢性阻塞性肺疾病急性加重高风险患者的临床效果分析
Clinical Effects of Budegraf Inhalation Aerosol and Tiotropium Bromide Combined with Formoterol in the Treatment of Patients at High Risk for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
艾红军 1彭娟2
作者信息
- 1. 上海市杨浦区控江医院呼吸内科,上海 200092
- 2. 上海市交通大学医学院附属新华医院呼吸内科,上海 200092
- 折叠
摘要
目的 对比布地格福吸入气雾剂与噻托溴铵联合福莫特罗治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重高风险患者的临床效果.方法 回顾性选取2023年1月—2024年1月上海市杨浦区控江医院收治的100例COPD急性加重高风险患者的临床资料.以不同治疗方法分为两组,每组50例,二联组采用噻托溴铵联合福莫特罗治疗,三联组采用布地格福吸入气雾剂治疗.对比两组急性加重次数、6分钟步行距离(6 minute walking test,6MWT)、肺功能水平和血气指标.结果 治疗后,三联组急性加重次数(2.23±0.69)次/年,少于二联组的(4.17±1.10)次/年,三联组6MWT为(423.47±39.56)m,长于二联组的(369.69±41.48)m,差异有统计学意义(t=10.564、6.634,P均<0.05).三联组肺功能水平、血气指标优于二联组,差异有统计学意义(P均<0.05).结论 在COPD急性加重高风险患者的治疗中,布地格福吸入气雾剂相较于噻托溴铵联合福莫特罗,能够更有效地减少急性加重次数,提升患者的运动耐量和肺功能,并改善血气指标.
Abstract
Objective To compare the clinical effectiveness of budesonide inhalation aerosol with tiotropium bromide in combination with formoterol in the treatment of patients at high risk for acute exacerbations of chronic obstructive pulmonary disease(COPD).Methods The clinical data of 100 patients with high risk of acute exacerbation of COPD admitted to Shanghai Yangpu District Kongjiang Hospital from January 2023 to January 2024 were retrospectively se-lected.They were divided into two groups according to different treatment methods,50 cases in each group,the dual group was treated with tiotropium bromide combined with formoterol,and the triple group was treated with budesonide inhalation aerosol.The number of acute exacerbations,6 minute walking test(6MWT),lung function level and blood gas indexes were compared between the two groups.Results After treatment,the number of acute exacerbations in the triple group was(2.23±0.69)times per year,which was less than(4.17±1.10)times per year in the dual group,and the 6MWT in the triple group was(423.47±39.56)m,which was longer than(369.69±41.48)m in the dual group,and the differences were statistically significant(t=10.564,6.634,both P<0.05).The lung function level and blood gas indexes of the triple group were better than those of the dual group,and the differences were statistically significant(all P<0.05).Conclusion In the treatment of patients at high risk for acute exacerbations of COPD,boudigrafin inhalation aerosol was more effective in reducing the number of acute exacerbations,enhancing exercise tolerance and lung func-tion,and improving blood gas indices compared with tiotropium bromide in combination with formoterol.
关键词
慢性阻塞性肺疾病/布地格福/噻托溴铵/福莫特罗/临床效果Key words
Chronic obstructive pulmonary disease/Budesonide/Tiotropium bromide/Formoterol/Clinical effects引用本文复制引用
出版年
2024
NETL
NSTL
万方数据