首页|安罗替尼治疗晚期肺癌患者的价值及安全性分析

安罗替尼治疗晚期肺癌患者的价值及安全性分析

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目的 探讨安罗替尼治疗晚期肺癌的价值及安全性.方法 非随机选取2021年12月—2023年4月安徽医科大学附属巢湖医院收治的60例晚期肺癌患者作为研究对象,依据治疗方案不同分两组,各30例.对照组实施单纯一线化疗,观察组在对照组基础上使用安罗替尼.对比两组临床疗效、不良反应发生率、生存质量、生存周期、肿瘤标志物水平.结果 观察组缓解率为73.33%(22/30),高于对照组的40.00%(12/30),差异有统计学意义(χ2=6.787,P<0.05).观察组不良反应发生率为20.00%(6/30),高于对照组的16.67%(5/30),但差异无统计学意义(χ2=0.111,P>0.05).治疗后,观察组生存质量、生存周期、肿瘤标志物水平均优于对照组,差异有统计学意义(P均<0.05).结论 安罗替尼治疗晚期肺癌患者安全性及有效性较高,在减轻肿瘤标志物水平的同时,延长其生存周期.
Analysis of the Value and Safety of Anlotinib in the Treatment of Patients with Advanced Lung Cancer
Objective To explore the value and safety of anlotinib in the treatment of advanced lung cancer.Methods From December 2021 to April 2023,sixty patients with advanced lung cancer admitted to Chaohu Hospital of Anhui Medical University were non-randomly selected as the research objects and divided into two groups according to dif-ferent treatment plans,thirty cases in each group.The control group was treated with first-line chemotherapy alone,and the observation group was treated with anlotinib on the basis of the control group.The clinical efficacy,incidence of adverse reactions,quality of life,life cycle and tumor marker levels were compared between the two groups.Results The remission rate of the observation group was 73.33%(22/30),which was higher than 40.00%(12/30)of the control group,and the difference was statistically significant(χ2=6.787,P<0.05).The incidence of adverse reactions in the ob-servation group was 20.00%(6/30),which was higher than 16.67%(5/30)in the control group,but the difference was not statistically significant(χ2=0.111,P>0.05).After treatment,the quality of life,life cycle and tumor marker levels in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Anlotinib is safe and effective in the treatment of patients with advanced lung cancer.It can reduce the level of tumor markers and prolong the life cycle of patients.

Tumor biomarker levelsAnlotinibAdvancedLung cancerAdverse reactionsSurvival cycle

李玲利、方晓琳、程苗

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安徽医科大学附属巢湖医院药物临床试验机构办公室,安徽 合肥 238000

肿瘤标志物水平 安罗替尼 晚期 肺癌 不良反应 生存周期

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(22)