Value of Soluble Suppression of Tumorigenesis 2 in Predicting the Formation of Coronary Collateral Circulation in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention
Objective To investigate the value of soluble suppression of tumorigenesis 2(sST2)in predicting the formation of coronary collateral circulation in patients with acute myocardial infarction after percutaneous coronary intervention.Methods A total of 85 patients with ST-elevation myocardial infarction(STEMI)who were admitted to The First People's Hospital of Jining from June 2020 to July 2023 and underwent emergency percutaneous coronary intervention(PCI)were enrolled as subjects.After admission,all patients underwent emergency PCI according to the latest guidelines for the treatment of acute STEMI,and standard angiography was performed to collect coronary collateral circulation data.Collateral circulation was graded according to the Rentrop's grading system:collateral circulation without filling any blood vessels as grade 0;small collateral filling as grade 1;partial epicardial artery filling as grade 2;complete epicardial artery perfusion as grade 3.Grades 0 and 1 were considered as poor collateral circulation formation,and grades 2 and 3 were considered as good collateral circulation formation.The patients were divided into good collateral circulation group with 33 patients and poor collateral circulation group with 52 patients.EUSA was used to measure the serum level of sST2 before intervention on day 1 of admission,and all patients underwent emergency PCI.General data were compared between the good collateral circulation group and the poor collateral circulation group.A logistic regression analysis was used to investigate risk factors,and the area under the ROC curve(AUC)was used to analyze the serum level of sST2 on admission and its value in predicting collateral circulation in patients with STEMI.Results The retrospective analysis showed that among the 85 patients,33 had good coronary collateral circulation and 52 had poor coronary collateral circulation,resulting in a rate of coronary collateral circulation of 38％.The poor collateral circulation group had a significantly higher serum level of sST2 than the good collateral circulation group(P＜0.05).The serum level of sST2 on admission had an AUC of 0.706(95％confidence interval:0.579-0.833,P＜0.05)in predicting collateral circulation after PCI in patients with STEMI.Conclusion The level of sST2 has a good value in predicting the formation of coronary collateral circulation in STEMI patients.
Soluble suppression of tumorigenesis 2ST-elevation myocardial infarctionCollateral circulationPredictive value
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