Pathogenesis and Treatment of Pulmonary Hypertension Associated with Atrial Septal Defect
Atrial septal defect(ASD)is a common congenital heart disease,and some patients may develop pulmonary hypertension(PH),which has a significant impact on treatment and prognosis.Although shunt is a decisive factor in the occurrence of PH in patients with congenital heart disease,the shunt flow in some patients is not sufficient to explain the severity of PH.Therefore,elucidating the multifaceted pathogenesis of PH associated with ASD is of great significance for understanding the occurrence and development process of PH and guiding the treatment of ASD.This article summarizes the advances in the pathophysiological mechanisms,risk factors,and treatment strategies of PH associated with ASD,providing reference for the diagnosis and treatment of such patients.
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