Hypoxic pulmonary hypertension(HPH)is a pulmonary vascular disease resulted from progressive increase in pulmonary arterial pressure caused by hypoxia.Hypoxia inducible factor-1(HIF-1)is a core transcription factor which maintains cell oxygen homeostasis,promotes the transformation of glucose metabolism patterns,regulates the activity of the ion channel on the membrane surface and the pulmonary vasoconstriction and relaxation factors,which plays an important role in the occurrence and development of HPH.This review aims to investigate the mechanism of HIF-1 and its downstream signaling molecules in the occurrence and development of HPH,which will provide new theoretical basis and therapeutic target for the treatment of HPH.
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